Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99305
Type: Journal article
Title: Modeling development and disease in the enteric nervous system
Author: Landman, K.
Binder, B.
Newgreen, D.
Citation: Journal of Cellular Automata, 2014; 9(2-3):95-109
Publisher: Old City Publishing
Issue Date: 2014
ISSN: 1557-5969
1557-5977
Statement of
Responsibility: 
Kerry A. Landman, Benjamin J. Binder and Donald F. Newgreen
Abstract: The enteric nervous system (ENS) in our gastrointestinal tract is responsible for normal gut function, including peristaltic contraction. Embryonic development of the ENS involves the colonization of the gut wall from one end to the other by a population of proliferating neural crest (NC) cells. Failure of these cells to invade the whole gut results in the relatively common, potentially fatal condition known as Hirschsprung disease (HSCR). Probabilistic cellular automata (CA) models provide insight into the colonization process. At the population level, the results exhibit an organised colonization wave, which extends through frontal expansion. Under a certain range of proliferation probabilities, the success or failure of colonization in the CA models is not certain, but probabilistic. At the individual level, a full exploration of agent progeny provides insight into a highly unequal clonal contributions. The CA models generated experimentally testable predictions, which have subsequently been confirmed. The model results imply that HSCR is chiefly a NC cell proliferation defect and not, as previously thought, a NC cell motil-ity defect. The phenomenon of incomplete penetrance seen in a number of birth defects including HSCR, where possession of a dominant causative mutation does not ensure the defect, is also explained by the CA results. [ABSTRACT FROM AUTHOR]
Keywords: Cellular automata; motility; proliferation; frontal expansion; stochastic; clones; hirschsprung disease
Rights: © Old City Publishing, Inc.
RMID: 0030012067
Appears in Collections:Mathematical Sciences publications

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