Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99329
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Type: Journal article
Title: Placental adaptations in growth restriction
Author: Zhang, S.
Regnault, T.
Barker, P.
Botting, K.
McMillen, I.
McMillan, C.
Roberts, C.
Morrison, J.
Citation: Nutrients, 2015; 7(1):360-389
Publisher: MDPI AG
Issue Date: 2015
ISSN: 2072-6643
2072-6643
Statement of
Responsibility: 
Song Zhang, Timothy R.H. Regnault, Paige L. Barker, Kimberley J. Botting, Isabella C. McMillen, Christine M. McMillan, Claire T. Roberts and Janna L. Morrison
Abstract: The placenta is the primary interface between the fetus and mother and plays an important role in maintaining fetal development and growth by facilitating the transfer of substrates and participating in modulating the maternal immune response to prevent immunological rejection of the conceptus. The major substrates required for fetal growth include oxygen, glucose, amino acids and fatty acids, and their transport processes depend on morphological characteristics of the placenta, such as placental size, morphology, blood flow and vascularity. Other factors including insulin-like growth factors, apoptosis, autophagy and glucocorticoid exposure also affect placental growth and substrate transport capacity. Intrauterine growth restriction (IUGR) is often a consequence of insufficiency, and is associated with a high incidence of perinatal morbidity and mortality, as well as increased risk of cardiovascular and metabolic diseases in later life. Several different experimental methods have been used to induce placental insufficiency and IUGR in animal models and a range of factors that regulate placental growth and substrate transport capacity have been demonstrated. While no model system completely recapitulates human IUGR, these animal models allow us to carefully dissect cellular and molecular mechanisms to improve our understanding and facilitate development of therapeutic interventions.
Keywords: Placental morphology; vascularity; substrate transport; IUGR
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
RMID: 0030023107
DOI: 10.3390/nu7010360
Grant ID: http://purl.org/au-research/grants/nhmrc/1066916
http://purl.org/au-research/grants/nhmrc/1020749
Appears in Collections:Medicine publications

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