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Type: Journal article
Title: The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health?
Author: Padhee, M.
Zhang, S.
Lie, S.
Wang, K.
Botting, K.
Caroline McMillen, I.
Maclaughlin, S.
Morrison, J.
Citation: Nutrients, 2015; 7(3):1378-1425
Publisher: MDPI AG
Issue Date: 2015
ISSN: 2072-6643
Statement of
Monalisa Padhee, Song Zhang, Shervi Lie, Kimberley C. Wang, Kimberley J. Botting, I. Caroline McMillen, Severence M. MacLaughlin and Janna L. Morrison
Abstract: Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs.
Keywords: Assisted reproductive technology; in vitro fertilization; periconceptional period; cardiovascular disease; epigenetics
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
RMID: 0030033390
DOI: 10.3390/nu7031378
Grant ID:
Appears in Collections:Obstetrics and Gynaecology publications

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