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dc.contributor.authorSime, F.en
dc.contributor.authorRoberts, M.en
dc.contributor.authorWarner, M.en
dc.contributor.authorHahn, U.en
dc.contributor.authorRobertson, T.en
dc.contributor.authorYeend, S.en
dc.contributor.authorPhay, A.en
dc.contributor.authorLehman, S.en
dc.contributor.authorLipman, J.en
dc.contributor.authorPeake, S.en
dc.contributor.authorRoberts, J.en
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2014; 58(6):3533-3537en
dc.description.abstractThis study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.en
dc.description.statementofresponsibilityFekade Bruck Sime, Michael S. Roberts, Morgyn S. Warner, Uwe Hahn, Thomas A. Robertson, Sue Yeend, Andy Phay, Sheila Lehman, Jeffrey Lipman, Sandra L. Peake, Jason A. Robertsen
dc.publisherAmerican Society for Microbiologyen
dc.rightsCopyright © 2014, American Society for Microbiology. All Rights Reserved.en
dc.subjectHumans; Hematologic Neoplasms; Neutropenia; Fever; Piperacillin; Anti-Bacterial Agents; Aged; Middle Aged; Female; Maleen
dc.titleAltered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancyen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidWarner, M. [0000-0002-4053-1610]en
dc.identifier.orcidPeake, S. [0000-0001-6682-7973]en
Appears in Collections:Medicine publications

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