Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/99485
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dc.contributor.authorSime, F.B.-
dc.contributor.authorRoberts, M.S.-
dc.contributor.authorWarner, M.S.-
dc.contributor.authorHahn, U.-
dc.contributor.authorRobertson, T.A.-
dc.contributor.authorYeend, S.-
dc.contributor.authorPhay, A.-
dc.contributor.authorLehman, S.-
dc.contributor.authorLipman, J.-
dc.contributor.authorPeake, S.L.-
dc.contributor.authorRoberts, J.A.-
dc.date.issued2014-
dc.identifier.citationAntimicrobial Agents and Chemotherapy, 2014; 58(6):3533-3537-
dc.identifier.issn0066-4804-
dc.identifier.issn1098-6596-
dc.identifier.urihttp://hdl.handle.net/2440/99485-
dc.description.abstractThis study assessed the pharmacokinetics and dosing adequacy of piperacillin in febrile neutropenic patients after the first dose. Pharmacokinetic analysis was performed using noncompartmental methods. We observed an elevated volume of distribution (29.7 ± 8.0 liters [mean ± standard deviation]) and clearance (20.2 ± 7.5 liters/h) compared to data from other patient populations. Antibiotic exposure did not consistently result in therapeutic targets. We conclude that alternative dosing strategies guided by therapeutic drug monitoring may be required to optimize exposure.-
dc.description.statementofresponsibilityFekade Bruck Sime, Michael S. Roberts, Morgyn S. Warner, Uwe Hahn, Thomas A. Robertson, Sue Yeend, Andy Phay, Sheila Lehman, Jeffrey Lipman, Sandra L. Peake, Jason A. Roberts-
dc.language.isoen-
dc.publisherAmerican Society for Microbiology-
dc.rightsCopyright © 2014, American Society for Microbiology. All Rights Reserved.-
dc.subjectHumans-
dc.subjectHematologic Neoplasms-
dc.subjectNeutropenia-
dc.subjectFever-
dc.subjectPiperacillin-
dc.subjectAnti-Bacterial Agents-
dc.subjectAged-
dc.subjectMiddle Aged-
dc.subjectFemale-
dc.subjectMale-
dc.titleAltered pharmacokinetics of piperacillin in febrile neutropenic patients with hematological malignancy-
dc.typeJournal article-
dc.identifier.doi10.1128/AAC.02340-14-
pubs.publication-statusPublished-
dc.identifier.orcidWarner, M.S. [0000-0002-4053-1610]-
dc.identifier.orcidPeake, S.L. [0000-0001-6682-7973]-
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