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Type: Journal article
Title: Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art
Author: Vanhoecke, B.
Bateman, E.
Mayo, B.
Vanlancker, E.
Stringer, A.
Thorpe, D.
Keefe, D.
Citation: Experimental Biology and Medicine, 2015; 240(6):725-741
Publisher: SAGE Publications
Issue Date: 2015
ISSN: 1535-3702
Statement of
Barbara Vanhoecke, Emma Bateman, Bronwen Mayo, Eline Vanlancker, Andrea Stringer, Daniel Thorpe and Dorothy Keefe
Abstract: Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate-, 5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.
Keywords: Rat; mucositis; methotrexate; 5-fluorouracil; irinotecan; chemotherapy
Rights: Copyright © 2015 by the Society for Experimental Biology and Medicine
RMID: 0030035037
DOI: 10.1177/1535370215581309
Appears in Collections:Medicine publications

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