Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/99688
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Type: Journal article
Title: Trichomonas vaginalis as a cause of perinatal morbidity: a systematic review and meta-analysis
Author: Silver, B.
Guy, R.
Kaldor, J.
Jamil, M.
Rumbold, A.
Citation: Sexually Transmitted Diseases, 2014; 41(6):369-376
Publisher: Lippincott, Williams & Wilkins
Issue Date: 2014
ISSN: 0148-5717
1537-4521
Statement of
Responsibility: 
Bronwyn J. Silver, Rebecca J. Guy, John M. Kaldor, Muhammad S. Jamil, and Alice R. Rumbold
Abstract: Trichomonas vaginalis is the most common curable sexually transmissible infection worldwide, with high rates in women of reproductive age. There have been inconsistent findings about the impact of infection and its treatment in pregnancy. We conducted a meta-analysis to determine the association between T. vaginalis and perinatal outcomes. Electronic databases were searched to May 2013. Included studies reported perinatal outcomes in women infected and uninfected with T. vaginalis. Meta-analysis calculated a pooled relative risk (RR) and 95% confidence interval (CI) using either a fixed- or random-effects model. Study bias was assessed using funnel plots. Of 178 articles identified, 11 studies met the inclusion criteria. The study populations, outcomes, and quality varied. T. vaginalis in pregnancy was associated with an increased risk of preterm birth (RR, 1.42; 95% CI, 1.15-1.75; 9 studies; n = 81,101; I = 62.7%), preterm premature rupture of membranes (RR, 1.41; 95% CI,1.10-1.82; 2 studies; n = 14,843; I = 0.0%) and small for gestational age infants (RR, 1.51; 95% CI,1.32-1.73; 2 studies; n = 14,843; I = 0.0%). Sensitivity analyses of studies that accounted for coinfection with other sexually transmissible infection found a slightly reduced RR of 1.34 for preterm birth (95% CI, 1.19-1.51; 6 studies; n = 72,077; I = 11.2%), and in studies where no treatment was confirmed, the RR was 1.83 (95% CI, 0.98-3.41; 3 studies; n = 1795; I = 22.3%). Our review provides strong evidence that T. vaginalis in pregnancy is associated with an increased risk of preterm birth. Based on fewer studies, there were also substantial increases in the risk of preterm premature rupture of membranes and small for gestational age infants. Further studies that address the current gaps in evidence on treatment effects in pregnancy are needed.
Keywords: Trichomonas vaginalis
Rights: Copyright © 2014 by the American Sexually Transmitted Diseases Association.
DOI: 10.1097/OLQ.0000000000000134
Grant ID: http://purl.org/au-research/grants/nhmrc/568971
Appears in Collections:Aurora harvest 3
Paediatrics publications

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