Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/99739
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dc.contributor.author | Grieger, J. | - |
dc.contributor.author | Clifton, V. | - |
dc.contributor.author | Tuck, A. | - |
dc.contributor.author | Wooldridge, A. | - |
dc.contributor.author | Robertson, S. | - |
dc.contributor.author | Gatford, K. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | International Archives of Allergy and Applied Immunology, 2016; 169(2):80-92 | - |
dc.identifier.issn | 1018-2438 | - |
dc.identifier.issn | 1423-0097 | - |
dc.identifier.uri | http://hdl.handle.net/2440/99739 | - |
dc.description.abstract | Background: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions. | - |
dc.description.statementofresponsibility | Jessica A. Grieger, Vicki L. Clifton, Astrud R. Tuck, Amy L. Wooldridge, Sarah A. Robertson, Kathryn L. Gatford | - |
dc.language.iso | en | - |
dc.publisher | Karger | - |
dc.rights | © 2016 S. Karger AG, Basel | - |
dc.source.uri | http://dx.doi.org/10.1159/000443961 | - |
dc.subject | Placenta | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Prenatal Exposure Delayed Effects | - |
dc.subject | Hypersensitivity | - |
dc.subject | Disease Susceptibility | - |
dc.subject | Diet | - |
dc.subject | Risk Factors | - |
dc.subject | Maternal Exposure | - |
dc.subject | Immunity, Maternally-Acquired | - |
dc.subject | DNA Methylation | - |
dc.subject | Epigenesis, Genetic | - |
dc.subject | Pregnancy | - |
dc.subject | Dietary Supplements | - |
dc.subject | Infant, Newborn | - |
dc.subject | Female | - |
dc.title | In utero Programming of Allergic Susceptibility | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1159/000443961 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1041918 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Grieger, J. [0000-0003-1515-948X] | - |
dc.identifier.orcid | Clifton, V. [0000-0002-4892-6748] | - |
dc.identifier.orcid | Wooldridge, A. [0000-0002-2914-7693] | - |
dc.identifier.orcid | Robertson, S. [0000-0002-9967-0084] | - |
dc.identifier.orcid | Gatford, K. [0000-0002-2823-3004] | - |
Appears in Collections: | Aurora harvest 7 Obstetrics and Gynaecology publications |
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