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dc.contributor.authorGrieger, J.-
dc.contributor.authorClifton, V.-
dc.contributor.authorTuck, A.-
dc.contributor.authorWooldridge, A.-
dc.contributor.authorRobertson, S.-
dc.contributor.authorGatford, K.-
dc.identifier.citationInternational Archives of Allergy and Applied Immunology, 2016; 169(2):80-92-
dc.description.abstractBackground: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. Methods: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood. Results: Exposures including maternal cigarette smoking, preterm birth and Caesarean delivery are implicated in predisposing infants to the later development of allergy. In contrast, restricted growth in utero, a healthy maternal diet and a larger family size are protective, but the mechanisms here are unclear and require further investigation. Conclusion: To ameliorate the allergy pandemic in young children, we must define prenatal mechanisms that alter the programming of the fetal immune system and also identify specific targets for antenatal interventions.-
dc.description.statementofresponsibilityJessica A. Grieger, Vicki L. Clifton, Astrud R. Tuck, Amy L. Wooldridge, Sarah A. Robertson, Kathryn L. Gatford-
dc.rights© 2016 S. Karger AG, Basel-
dc.subjectPrenatal Exposure Delayed Effects-
dc.subjectDisease Susceptibility-
dc.subjectRisk Factors-
dc.subjectMaternal Exposure-
dc.subjectImmunity, Maternally-Acquired-
dc.subjectDNA Methylation-
dc.subjectEpigenesis, Genetic-
dc.subjectDietary Supplements-
dc.subjectInfant, Newborn-
dc.titleIn utero Programming of Allergic Susceptibility-
dc.typeJournal article-
dc.identifier.orcidGrieger, J. [0000-0003-1515-948X]-
dc.identifier.orcidClifton, V. [0000-0002-4892-6748]-
dc.identifier.orcidWooldridge, A. [0000-0002-2914-7693]-
dc.identifier.orcidRobertson, S. [0000-0002-9967-0084]-
dc.identifier.orcidGatford, K. [0000-0002-2823-3004]-
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