Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99754
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women
Author: Andraweera, P.
Dekker, G.
Jayasekara, R.
Dissanayake, V.
Roberts, C.
Citation: Journal of Maternal-Fetal & Neonatal Medicine, 2016; 29(7):1072-1076
Publisher: Taylor & Francis Ltd.
Issue Date: 2016
ISSN: 1476-7058
1476-4954
Statement of
Responsibility: 
Prabha H. Andraweera, Gustaaf A Dekker, Rohan W. Jayasekara, Vajira H.W. Dissanayake, and Claire T. Roberts
Abstract: Objective: Elevated pro-inflammatory cytokines play an important role in the pathogenesis of preeclampsia. We investigated the prevalence of functional polymorphisms in genes regulating inflammation in preeclamptic women. Methods: One hundred seventy-five nulliparous Sinhalese women with preeclampsia (cases) and 171 normotensive women matched for age, ethnicity, parity and body mass index (BMI) (controls) were recruited. Preeclampsia was diagnosed using international guidelines. Genotyping was performed on DNA extracted from peripheral blood using the Sequenom MassARRAY system. Results: The prevalence of the CT genotype of IL1A rs17561 polymorphism was increased in preeclamptic women compared with controls {p = 0.04, odds ratio (OR) [95% class interval (CI)] = 1.6 (1.0-2.5)}. The prevalence of the CT genotype [p = 0.01, OR (95% CI) = 1.8 (1.1-2.8)] and the dominant model (CT + TT) [p = 0.03, OR (95% CI) = 1.6 (1.1-2.5)] of the IL1A rs1800587 polymorphism were increased in preeclamptic women compared with controls. The prevalence of the GA genotype [p = 0.04, OR (95% CI) = 0.6 (0.4-0.9)] and the dominant model (GA + AA) [p = 0.03, OR (95% CI) = 0.6 (0.4-0.9)] of the MBL1 rs1800450 polymorphism were reduced in preeclamptic women compared to controls. Conclusion: Genotypes conferring a pro-inflammatory phenotype are increased in preeclamptic women.
Keywords: Inflammation; interleukin; polymorphism; preeclampsia
Rights: © 2015 Informa UK Ltd.
RMID: 0030027571
DOI: 10.3109/14767058.2015.1034102
Grant ID: http://purl.org/au-research/grants/nhmrc/519225
http://purl.org/au-research/grants/nhmrc/1020749
http://purl.org/au-research/grants/nhmrc/1090778
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.