Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99926
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Type: Journal article
Title: The moose, purine degradation, and environmental adaptation
Author: Zhang, W.
Stott, P.
Zhang, M.
Citation: European Journal of Wildlife Research, 2014; 60(6):937-939
Publisher: Springer
Issue Date: 2014
ISSN: 1612-4642
1439-0574
Statement of
Responsibility: 
Weiqi Zhang, Philip Stott, Minghai Zhang
Abstract: It is accepted that allantoin is the end-product of purine degradation in mammals, except that uricase activity has been lost during the evolution of humans in which uric acid protects the brain from oxidative damage. However, we have found that the moose Alces americanus excretes extremely low urinary concentrations of allantoin and high concentrations of uric acid very similar to those of humans. Exposure to extreme cold is known to cause oxidative damage, and we suggest that the retention of uric acid by the moose represents an adaptation enabling the species to survive at high latitudes.
Keywords: Alces americanus; China; purine degradation; uric acid
Rights: © The Author(s) 2014. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
RMID: 0030012803
DOI: 10.1007/s10344-014-0865-5
Appears in Collections:Animal and Veterinary Sciences publications

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