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Type: Journal article
Title: Quatsomes for the treatment of Staphylococcus aureus biofilm
Author: Thomas, N.
Dong, D.
Richter, K.
Ramezanpour, M.
Vreugde, S.
Thierry, B.
Wormald, P.
Prestidge, C.
Citation: Journal of Materials Chemistry B, 2015; 3(14):2770-2777
Publisher: Royal Society of Chemistry
Issue Date: 2015
ISSN: 2050-7518
Statement of
Nicky Thomas, Dong Dong, Katharina Richter, Mahnaz Ramezanpour, Sarah Vreugde, Benjamin Thierry, Peter-John Wormald and Clive A. Prestidge
Abstract: The anti-biofilm effect of drug delivery systems composed of the antiseptic quaternary ammonium compound cetylpyridinium chloride (CPC) and cholesterol was evaluated in Staphylococcus aureus biofilm. Self-assembly of CPC/cholesterol to approximately 100 nm CPC-quatsomes was successfully accomplished by a simple sonication/dispersion method over a broad concentration range from 0.5 to 10 mg ml−1 CPC. CPC-quatsomes showed a dose-dependent anti-biofilm effect, killing >99% of biofilm-associated S. aureus from 5% mg ml−1 after 10 minutes exposure. Cell toxicity studies with CPC-quatsomes in Nuli-1 cells revealed no adverse effects at all tested CPC concentrations. CPC-quatsomes, therefore, have a promising potential as novel drug delivery systems with “built-in” anti-biofilm activity.
Rights: This journal is © The Royal Society of Chemistry 2015
DOI: 10.1039/c4tb01953a
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