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Type: Journal article
Title: Cancer-cell-specific nuclear-targeted drug delivery by dual-ligand-modified mesoporous silica nanoparticles
Author: Xiong, L.
Du, X.
Kleitz, F.
Qiao, S.
Citation: Small, 2015; 11(44):5919-5926
Publisher: Wiley-VCH Verlag
Issue Date: 2015
ISSN: 1613-6810
Statement of
Lin Xiong, Xin Du, Freddy Kleitz and Shi Zhang Qiao
Abstract: Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
Keywords: cancer therapy
drug delivery
mesoporous silica
Rights: © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/smll.201501056
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Chemical Engineering publications

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