Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/99992
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Cancer-cell-specific nuclear-targeted drug delivery by dual-ligand-modified mesoporous silica nanoparticles
Author: Xiong, L.
Du, X.
Kleitz, F.
Qiao, S.
Citation: Small, 2015; 11(44):5919-5926
Publisher: Wiley-VCH Verlag
Issue Date: 2015
ISSN: 1613-6810
1613-6829
Statement of
Responsibility: 
Lin Xiong, Xin Du, Freddy Kleitz and Shi Zhang Qiao
Abstract: Mesoporous silica nanoparticles are modified with dual targeting ligands, i.e., folic acid and dexamethasone, to construct a cancer-cell-specific nuclear-targeted delivery system. The resulting nanocarriers can not only enhance the inhibition efficacy of doxorubicin on Hela cells through active nucleus accumulation but also reduce toxic side effects on noncancer cells though receptor-mediated selective cellular uptake.
Keywords: cancer therapy
dexamethasone
doxorubicin
drug delivery
mesoporous silica
Rights: © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI: 10.1002/smll.201501056
Grant ID: http://purl.org/au-research/grants/arc/DP130104459
http://purl.org/au-research/grants/arc/DP140104062
Appears in Collections:Aurora harvest 7
Chemical Engineering publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.