Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model
Date
2018
Authors
Lin, Y.W.
Zhou, Q.T.
Han, M.L.
Chen, K.
Onufrak, N.J.
Wang, J.
Turnidge, J.D.
Howden, B.P.
Forrest, A.
Chan, H.K.
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Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2018; 62(2):e01790-1-e0179-17
Statement of Responsibility
Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak-Kim Chan, Jian Lih
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Abstract
The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.
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© 2018 American Society for Microbiology. All Rights Reserved.