Bone fracture and bone fracture repair

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dc.contributor.authorFazzalari, N.
dc.contributor.conferenceBone Quality Seminars : Osteoporosis International)
dc.date.issued2011
dc.description.abstractFracture healing is a multistage repair process that involves complex, well-orchestrated steps initiated in response to tissue injury. The early upregulation of IL-6, osteoprotegerin (OPG), VEGF, and BMPs indicates a central role for these factors in the initiation of cartilage and periosteal woven bone formation. In both callus fracture repair and stress fracture repair, the RANKL/OPG ratio is initially reduced, but peaks earlier in stress fracture healing than callus fracture healing. Though the understanding of the biological processes and molecular signals that coordinate fracture repair has advanced, the cause of variability observed in fracture repair is poorly understood.
dc.description.statementofresponsibilityN. L. Fazzalari
dc.identifier.citationOsteoporosis International, 2011, vol.22, iss.6, pp.2003-2006
dc.identifier.doi10.1007/s00198-011-1611-4
dc.identifier.issn0937-941X
dc.identifier.issn1433-2965
dc.identifier.urihttp://hdl.handle.net/2440/71870
dc.language.isoen
dc.publisherSpringer London Ltd
dc.publisher.placeSweetapple House Catteshall Road Godalming England GU7 3DJ
dc.rights© International Osteoporosis Foundation and National Osteoporosis Foundation 2011
dc.source.urihttps://doi.org/10.1007/s00198-011-1611-4
dc.subjectFracture
dc.subjectfracture repair
dc.subjectmicrodamage
dc.subjectstress
dc.titleBone fracture and bone fracture repair
dc.typeConference paper
pubs.publication-statusPublished

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