Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy
Date
2013
Authors
Sivakumar, B.
Aswathy, R.G.
Nagaoka, Y.
Iwai, S.
Venugopal, K.
Kato, K.
Yoshida, Y.
Maekawa, T.
Sakthi, K.D.N.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
RSC Advances, 2013; 3(43):20579-20598
Statement of Responsibility
Conference Name
Abstract
Pancreatic cancer is the fifth leading cause of cancer related deaths worldwide. Currently, finding an effective drug delivery strategy in pancreatic cancer treatment is a major challenge. Nanotechnology offers an indispensible function by precisely delivering anticancer therapeutics in a targeted method to the cancer specific cells thus sparing normal healthy cells and hence resulting in an enhanced efficiency. The development of designer multifunctional therapeutics with magnetic nanoparticles (MNP) is a promising approach to selectively deliver therapeutics and image them in cancer cells. This study explored the preparation, characterization and application of a targeted nanosystem represented by an aptamer conjugated dual drug (curcumin and gemcitabine-loaded) and MNP encapsulated PLGA nanoparticles (Apt-Cur-Gem-PLGA- MNPs) for pancreatic cancer therapy. The aptamer targeted NPs exhibited excellent antiproliferative activity leading to apoptosis owing to enhanced cellular uptake. The presence of MNP in the nanoconjugate was exploited for magnetic hyperthermia and magnetic ablation of cancer cells by a rotating magnetic field. Thus, Apt-Cur-Gem-PLGA-MNPs is able to deliver an effective and targeted delivery of therapeutics for pancreatic cancer treatment.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2013 Royal Society of Chemistry