Exposure to solar UVR suppresses cell-mediated immunization responses in humans: the Australian ultraviolet radiation and immunity study
Date
2019
Authors
Swaminathan, A.
Harrison, S.L.
Ketheesan, N.
van den Boogaard, C.H.A.
Dear, K.
Allen, M.
Hart, P.H.
Cook, M.
Lucas, R.M.
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Journal article
Citation
Journal of Investigative Dermatology, 2019; 139(7):1545-1553.e6
Statement of Responsibility
Ashwin Swaminathan, Simone L. Harrison, Natkunam Ketheesan, Christel H.A. van den Boogaard, Keith Dear, Martin Allen ... et al.
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Abstract
Animal and human studies show that exposure to solar-simulated UVR is immunomodulatory. Human studies that used natural sun exposure and controlled for confounding are rare. We immunized 217 healthy adults (age range = 18-40 years) with a T-cell-dependent antigen, keyhole limpet hemocyanin, and measured personal clothing-adjusted UVR exposure (for 5 days before and after immunization), lifetime cumulative UVR exposure, serum 25-hydroxyvitamin D concentration at immunization, and potential confounding factors. We tested cellular and humoral immune responses in relation to UVR exposure. The delayed-type hypersensitivity response to keyhole limpet hemocyanin recall challenge was lower in individuals with higher personal clothing-adjusted UVR exposure on the day before immunization (P = 0.015) and during intervals spanning the day before to 2-3 days after immunization. There was an incremental increase in T helper type 17 cells (as a proportion of CD4+ T cells) from preimmunization to postimmunization in the high, compared with the low, personal clothing-adjusted UVR exposure group (0.31% vs. -0.39%, P = 0.004). Keyhole limpet hemocyanin-specific antibody titers were not associated with acute or cumulative UVR exposure or serum 25-hydroxyvitamin D levels. Higher UVR exposure at antigen sensitization was associated with a reduced delayed-type hypersensitivity response and altered T helper type 17 kinetics. This has implications for the effectiveness of vaccinations and susceptibility to infections that rely on cell-mediated immune responses.
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© 2019 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).