IGF2: an endocrine hormone to improve islet transplant survival

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dc.contributor.authorHughes, A.
dc.contributor.authorRojas-Canales, D.
dc.contributor.authorDrogemuller, C.
dc.contributor.authorVoelcker, N.
dc.contributor.authorGrey, S.
dc.contributor.authorCoates, P.
dc.date.issued2014
dc.description.abstractIn the week following pancreatic islet transplantation, up to 50% of transplanted islets are lost due to apoptotic cell death triggered by hypoxic and pro-inflammatory cytokine-mediated cell stress. Thus, therapeutic approaches designed to protect islet cells from apoptosis could significantly improve islet transplant success. IGF2 is an anti-apoptotic endocrine protein that inhibits apoptotic cell death through the mitochondrial (intrinsic pathway) or via antagonising activation of pro-inflammatory cytokine signalling (extrinsic pathway), in doing so IGF2 has emerged as a promising therapeutic molecule to improve islet survival in the immediate post-transplant period. The development of novel biomaterials coated with IGF2 is a promising strategy to achieve this. This review examines the mechanisms mediating islet cell apoptosis in the peri- and post-transplant period and aims to identify the utility of IGF2 to promote islet survival and enhance long-term insulin independence rates within the setting of clinical islet transplantation.
dc.description.statementofresponsibilityAmy Hughes, Darling Rojas-Canales, Chris Drogemuller, Nicolas H Voelcker, Shane T Grey and P T H Coates
dc.identifier.citationJournal of Endocrinology, 2014; 221(2):R41-R48
dc.identifier.doi10.1530/JOE-13-0557
dc.identifier.issn0022-0795
dc.identifier.issn1479-6805
dc.identifier.orcidDrogemuller, C. [0000-0001-9770-4845]
dc.identifier.orcidGrey, S. [0000-0003-2160-1625]
dc.identifier.urihttp://hdl.handle.net/2440/92579
dc.language.isoen
dc.publisherBioScientifica
dc.rights© 2014 Society for Endocrinology
dc.source.urihttps://doi.org/10.1530/joe-13-0557
dc.subjectinsulin-like growth factor; apoptosis; islets; cell survival; islet transplantation
dc.titleIGF2: an endocrine hormone to improve islet transplant survival
dc.typeJournal article
pubs.publication-statusPublished

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