Osteoporotic characteristics persist in the spine of ovariectomized sheep after withdrawal of corticosteroid administration

Simple item page
dc.contributor.authorZarrinkalam, M.
dc.contributor.authorSchultz, C.
dc.contributor.authorParkinson, I.
dc.contributor.authorMoore, R.
dc.date.issued2012
dc.description.abstractA validated ovine model of osteoporosis achieves severe bone loss in a relatively short period. This study investigated if osteoporotic features persist in this model after cessation of corticosteroid administration. Methods. Osteoporosis was induced in nine ewes by chronic corticosteroid injection, ovariectomy, and low calcium diet. Six ewes were used as controls. Bone mineral density (BMD) of the lumbar spine (LS) and body weight were assessed at regular intervals. After five months, corticosteroid treatment was withdrawn systematically over one month. Three months later, all animals were euthanised, and the LS was collected for histomorphometric analysis. Results. BMD in the LS of osteoporotic sheep was 25% lower than control sheep. Body weight of osteoporotic sheep was reduced in the first month of the corticosteroid withdrawal period but returned to baseline level thereafter. Trabecular bone volume of LS in osteoporotic sheep was 27% lower than controls and showed a heterogeneous structure. Conclusions. Osteoporotic characteristics remain in the vertebra after ceasing corticosteroid administration providing an opportunity to evaluate potential systemic or local treatments in vivo under realistic physiological conditions. The microstructural arrangement of vertebral trabecular bone in sheep is similar to humans demonstrating further relevance of this model for preclinical investigations.
dc.description.statementofresponsibilityMohammad-Reza Zarrinkalam, Christopher G. Schultz, Ian H. Parkinson and Robert J.Moore
dc.identifier.citationJournal of Osteoporosis, 2012; 2012:1-6
dc.identifier.doi10.1155/2012/182509
dc.identifier.issn2042-0064
dc.identifier.issn2042-0064
dc.identifier.urihttp://hdl.handle.net/2440/77713
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.rightsCopyright © 2012 Mohammad-Reza Zarrinkalam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1155/2012/182509
dc.titleOsteoporotic characteristics persist in the spine of ovariectomized sheep after withdrawal of corticosteroid administration
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_77713.pdf
Size:
2.22 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Medicine publications