The localisation of ED1 antibody in the resorbing hard tissues of the periodontium

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dc.contributor.authorDreyer, C.
dc.contributor.authorPierce, A.
dc.date.issued2001
dc.descriptionCopyright © 2007 Australian Orthodontic Journal
dc.description.abstractA dental hard tissue resorptive model was used to determine the periodontal ligament (PDL) distribution of lysosomal membrane antibody ED1 to cells of the macrophage-phagocyte lineage. Immunolabel was identified in mononuclear cells around inflammatory sites in the PDL, while multinuclear cells were labelled in resorption bays present in both bone and dentine. As repair of the tissues occurred, the label became less obvious. The presence of strong ED1 label in alveolar bone marrow provided evidence supporting the haemopoietic origin of the similarly labelled PDL cells. Also, evidence confirming the current theory that multinucleated resorptive cells differentiate along a monocyte-macrophage pathway was provided. t was concluded that ED1 is a positive PDL marker for mononuclear and multinuclear cells involved in the inflammatory and resorptive processes.
dc.description.urihttp://www.aso.org.au/AOJ/AOJ_docs/Past_issues/Vol_17_No_1.htm#4
dc.identifier.citationAustralian Orthodontic Journal, 2001; 17(1):35-40
dc.identifier.issn0587-3908
dc.identifier.orcidDreyer, C. [0000-0003-2053-5486]
dc.identifier.urihttp://hdl.handle.net/2440/1462
dc.language.isoen
dc.publisherAustralian Society of Orthodontists
dc.subjectMonocytes
dc.subjectIntracellular Membranes
dc.subjectCell Nucleus
dc.subjectLysosomes
dc.subjectMacrophages
dc.subjectPhagocytes
dc.subjectPeriodontal Ligament
dc.subjectDentin
dc.subjectBone Marrow
dc.subjectAnimals
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectBone Resorption
dc.subjectAlveolar Bone Loss
dc.subjectAnkylosis
dc.subjectDental Pulp Necrosis
dc.subjectTooth Resorption
dc.subjectDisease Models, Animal
dc.subjectAntibodies, Monoclonal
dc.subjectHematopoiesis
dc.subjectMale
dc.subjectBiomarkers
dc.titleThe localisation of ED1 antibody in the resorbing hard tissues of the periodontium
dc.typeJournal article
pubs.publication-statusPublished

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