Placental Shear Wave Elastography Assessment in Early and Late Fetal Growth Restriction

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dc.contributor.authorCavanagh, E.
dc.contributor.authorCrawford, K.
dc.contributor.authorHong, J.
dc.contributor.authorFontanarosa, D.
dc.contributor.authorEdwards, C.
dc.contributor.authorWille, M.-L.
dc.contributor.authorHong, J.
dc.contributor.authorClifton, V.L.
dc.contributor.authorKumar, S.
dc.date.issued2025
dc.description.abstractBackground/Objectives: The application of shear wave elastography (SWE) for the assessment of placental disease is still unproven and there is limited data correlating placental biomechanical properties with aberrations in fetal growth. This study investigated changes in placental shear wave velocity (SWV) in early and late fetal growth restriction (FGR). Methods: We analyzed three study cohorts: Pregnancies with appropriate growth for gestational age (AGA) and those with early (<32 weeks’) and late (>32 weeks’) FGR. Mean SWV at two time points was compared in the following cohorts: all FGR vs. AGA, early FGR vs. late FGR, early FGR vs. AGA, and late FGR vs. AGA. Results: The study comprised 222 women—79 (35.6%) FGR and 143 (64.4%) AGA. Of the FGR pregnancies, 37 (46.8%) were early and 42 (53.2%) were late. On multivariate analysis mean, SWV was not increased in FGR compared to AGA placentae (β 0.21, 95% CI −0.17–0.60, p 0.28). It was also not increased in early FGR compared to late FGR or AGA placentae (β 0.36, 95% CI −0.06–0.77, p 0.09). We observed an effect measure modification by pre-eclampsia, increasing mean SWV to a greater extent in AGA compared to FGR cases. Conclusions: Although previous studies have shown an association between placental SWV and FGR, our study showed no difference between cases and controls. The interaction of pre-eclampsia indicated that SWE may have a greater role in pre-eclampsia than in FGR alone. Further investigation of the influence of increased maternal vascular pressure on placental stiffness would be beneficial
dc.description.statementofresponsibilityErika Cavanagh, Kylie Crawford, Jesrine Hong, Davide Fontanarosa, Christopher Edwards, Marie-Luise Wille, Jennifer Hong, Vicki L. Clifton, and Sailesh Kumar
dc.identifier.citationJournal of Clinical Medicine, 2025; 14(14):4980-1-4980-13
dc.identifier.doi10.3390/jcm14144980
dc.identifier.issn2077-0383
dc.identifier.issn2077-0383
dc.identifier.orcidClifton, V.L. [0000-0002-4892-6748]
dc.identifier.urihttps://hdl.handle.net/2440/147717
dc.language.isoen
dc.publisherMDPI AG
dc.relation.grantNHMRC
dc.rights© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/ licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/jcm14144980
dc.subjectshear wave elastography; placental stiffness; placental elastography; fetal growth restriction; pre-eclampsia; ultrasound
dc.titlePlacental Shear Wave Elastography Assessment in Early and Late Fetal Growth Restriction
dc.typeJournal article
pubs.publication-statusPublished online

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