Autophagy in major human diseases
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(Published version)
Date
2021
Authors
Klionsky, D.J.
Petroni, G.
Amaravadi, R.K.
Baehrecke, E.H.
Kumar, S.
Pietrocola, F.
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EMBO Journal, 2021; 40(19, article no. e108863):1-63
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Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
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Copyright 2021 The Authors. Published under the terms of the CC BY 4.0 license (https://creativecommons.org/licenses/)