Application of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review

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dc.contributor.authorWillison, N.
dc.contributor.authorBehnia-Willison, F.
dc.contributor.authorAryan, P.
dc.contributor.authorPadhani, Z.A.
dc.contributor.authorMirzaei Damabi, N.
dc.contributor.authorNguyen, T.
dc.contributor.authorYi, J.
dc.contributor.authorDutta, R.
dc.contributor.authorAbbott, D.
dc.date.issued2025
dc.description.abstractPlatelet-rich plasma (PRP) therapy is a non-invasive, autologous treatment with regenerative potential in gynaecology beyond fertility applications. This review evaluates PRP in non-fertility-related gynaecological conditions affecting women’s quality of life (QoL). Methods: Following PRISMA-ScR guidelines, we searched Embase, CINAHL, Web of Science, Scopus, CENTRAL, and MEDLINE for studies on PRP in conditions such as vulvar lichen sclerosus (VLS), vulvovaginal atrophy (VVA), sexual dysfunction (SD), stress urinary incontinence (SUI), and interstitial cystitis/bladder pain syndrome (IC/BPS). Of 3660 records screened, 43 studies (randomised controlled trials, quasi-experimental, cohort, and case series) were included. Results: PRP improved symptoms and QoL in several conditions, particularly VLS and SD, and was generally well tolerated with minor adverse effects (e.g., injection-site pain, transient discomfort). Evidence for abnormal uterine bleeding (AUB) and pelvic organ prolapse (POP) was inconclusive. Considerable heterogeneity in preparation protocols and outcome measures limited cross-study comparison. Conclusions: PRP shows promise as a minimally invasive therapy for certain gynaecological conditions. Standardisation of preparation and administration, along with large-scale RCTs, is needed to determine long-term efficacy and safety.
dc.description.statementofresponsibilityNadia Willison, Fariba Behnia-Willison, Pouria Aryan, Zahra Ali Padhani, Negin Mirzaei Damabi, Tran Nguyen, Johnny Yi, Rituparna Dutta, and Derek Abbott
dc.identifier.citationJournal of Clinical Medicine, 2025; 14(16):5832-1-5832-20
dc.identifier.doi10.3390/jcm14165832
dc.identifier.issn2077-0383
dc.identifier.issn2077-0383
dc.identifier.orcidPadhani, Z.A. [0000-0003-4777-7565]
dc.identifier.orcidMirzaei Damabi, N. [0000-0003-3643-492X]
dc.identifier.orcidAbbott, D. [0000-0002-0945-2674]
dc.identifier.urihttps://hdl.handle.net/2440/148035
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/arc/FL240100217
dc.rights© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/jcm14165832
dc.subjectregenerative medicine; platelet rich plasma; gynaecological conditions; vulvar lichen sclerosus; urinary incontinence; pelvic floor
dc.titleApplication of Platelet-Rich Plasma in Gynaecologic Disorders: A Scoping Review
dc.typeJournal article
pubs.publication-statusPublished online

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