Intestinal mycoplasma in Crohn's disease
Date
2004
Authors
Roediger, W.
Editors
Chadwick, D.
Goode, J.
Goode, J.
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Book chapter
Citation
Inflammatory bowel disease: Crossroads of microbes, epithelium and immune systems, 2004 / Chadwick, D., Goode, J. (ed./s), vol.263, pp.85-98
Statement of Responsibility
W.E.W. Roediger
Conference Name
Abstract
Intestinal diversion with reconnection in active Crohn's disease (CD) indicates that luminal contents or bacteria contribute to the formation of CD lesions. Fluorescent staining for mycoplasma in freshly resected Crohn's tissue and electron microscopy reveal intracellular organisms akin to mycoplasma. Historically, tissue culture of CD has shown mycoplasma described as contaminants. Mycoplasma are surface epithelial parasites requiring exogenous cholesterol for membrane stability and cell entry. PCR of intestinal tissue has shown Mycoplasma pneumoniae to be detectable more significantly in CD. Oral M. iowae in experimental poultry localizes to the distal small bowel and colon. Hypothetically, lipopeptides of mycoplasmal membranes are proposed to cause chronicity and stronger immune responses than by other bacteria. 'Intestinal' mycoplasmas, from a number of observations, deserve consideration as organisms mediating inflammation of acute and chronic CD.