Carbapenem Resistance among Pseudomonas aeruginosa Strains from India: Evidence for Nationwide Endemicity of Multiple Metallo-beta-Lactamase Clones (VIM-2,-5,-6, and-11 and the Newly Characterized VIM-18)
Date
2009
Authors
Castanheira, M.
Bell, J.
Turnidge, J.
Mathai, D.
Jones, R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Antimicrobial Agents and Chemotherapy, 2009; 53(3):1225-1227
Statement of Responsibility
Mariana Castanheira, Jan M. Bell, John D. Turnidge, Dillip Mathai and Ronald N. Jones
Conference Name
Abstract
Among 57 metallo-beta-lactamase (MbetaL)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and MbetaL-carrying integrons.