SARS-CoV-2 Omicron variant escapes neutralising antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents.
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Date
2022
Authors
Garcia-Valtanen, P.
Hope, C.M.
Masavuli, M.G.
Yeow, A.E.L.
Balachandran, H.
Mekonnen, Z.A.
Al-Delfi, Z.
Abayasingam, A.
Agapiou, D.
Stella, A.O.
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Cell Reports Medicine, 2022; 3(6):100651-1-100651-17
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Coronavirus disease 2019 (COVID-19) convalescents living in regions with low vaccination rates rely on postinfection immunity for protection against re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We evaluate humoral and T cell immunity against five variants of concern (VOCs) in mild- COVID-19 convalescents at 12 months after infection with ancestral virus. In this cohort, ancestral, receptor- binding domain (RBD)-specific antibody and circulating memory B cell levels are conserved in most individuals, and yet serum neutralization against live B.1.1.529 (Omicron) is completely abrogated and significantly reduced for other VOCs. Likewise, ancestral SARS-CoV-2-specific memory T cell frequencies are maintained in >50% of convalescents, but the cytokine response in these cells to mutated spike epitopes corresponding to B.1.1.529 and B.1.351 (Beta) VOCs were impaired. These results indicate that increased antigen variability in VOCs impairs humoral and spike-specific T cell immunity post-infection, strongly suggesting that COVID-19 convalescents are vulnerable and at risk of re-infection with VOCs, thus stressing the importance of vaccination programs.
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© 2022 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).