Control of oocyte release by progesterone receptor-regulated gene expression

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dc.contributor.authorRobker, R.
dc.contributor.authorAkison, L.
dc.contributor.authorRussell, D.
dc.date.issued2009
dc.description.abstractThe progesterone receptor (PGR) is a nuclear receptor transcription factor that is essential for female fertility, in part due to its control of oocyte release from the ovary, or ovulation. In all mammals studied to date, ovarian expression of PGR is restricted primarily to granulosa cells of follicles destined to ovulate. Granulosa cell expression of PGR is induced by the pituitary Luteinizing Hormone (LH) surge via mechanisms that are not entirely understood, but which involve activation of Protein Kinase A and modification of Sp1/Sp3 transcription factors on the PGR promoter. Null mutations for PGR or treatment with PGR antagonists block ovulation in all species analyzed, including humans. The cellular mechanisms by which PGR regulates ovulation are currently under investigation, with several downstream pathways having been identified as PGR-regulated and potentially involved in follicular rupture. Interestingly, none of these PGR-regulated genes has been demonstrated to be a direct transcriptional target of PGR. Rather, in ovarian granulosa cells, PGR may act as an inducible coregulator for constitutively bound Sp1/Sp3 transcription factors, which are key regulators for a discrete cohort of ovulatory genes.
dc.description.statementofresponsibilityRebecca L. Robker, Lisa K. Akison and Darryl L. Russell
dc.identifier.citationNuclear Receptor Signaling, 2009; 7(1):1-12
dc.identifier.doi10.1621/nrs.07012
dc.identifier.issn1550-7629
dc.identifier.issn1550-7629
dc.identifier.orcidRobker, R. [0000-0002-1538-4604]
dc.identifier.orcidRussell, D. [0000-0002-4930-7658]
dc.identifier.urihttp://hdl.handle.net/2440/58639
dc.language.isoen
dc.publisherNuclear Receptor Signaling Atlas
dc.rightsCopyright © 2009, Robker et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1621/nrs.07012
dc.subjectOvary
dc.subjectGranulosa Cells
dc.subjectOocytes
dc.subjectAnimals
dc.subjectPrimates
dc.subjectHumans
dc.subjectMice
dc.subjectRats
dc.subjectLuteinizing Hormone
dc.subjectReceptors, Progesterone
dc.subjectTranscription Factors
dc.subjectGene Expression Regulation
dc.subjectOvulation
dc.subjectFemale
dc.titleControl of oocyte release by progesterone receptor-regulated gene expression
dc.typeJournal article
pubs.publication-statusPublished

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