Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
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(Accepted version)
Date
2018
Authors
Li, J.
Schartner, E.
Musolino, S.
Quirk, B.
Kirk, R.
Ebendorff-Heidepriem, H.
McLaughlin, R.
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Journal article
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Optics Letters, 2018; 43(8):1682-1685
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Jiawen Li, Erik Schartner, Stefan Musolino, Bryden C. Quirk, Rodney W. Kirk, Heike Ebendorff-Heidepriem and Robert A. McLaughlin
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Abstract
The ability to visualize structure whilst simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double clad fiber, including a thin layer of rare-earth doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.
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© 2018 Optical Society of America