Miniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue

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dc.contributor.authorLi, J.
dc.contributor.authorSchartner, E.
dc.contributor.authorMusolino, S.
dc.contributor.authorQuirk, B.
dc.contributor.authorKirk, R.
dc.contributor.authorEbendorff-Heidepriem, H.
dc.contributor.authorMcLaughlin, R.
dc.date.issued2018
dc.description.abstractThe ability to visualize structure whilst simultaneously measuring chemical or physical properties of a biological tissue has the potential to improve our understanding of complex biological processes. We report the first miniaturized single-fiber-based imaging+sensing probe capable of simultaneous optical coherence tomography (OCT) imaging and temperature sensing. An OCT lens is fabricated at the distal end of a double clad fiber, including a thin layer of rare-earth doped tellurite glass to enable temperature measurements. The high refractive index of the tellurite glass enables a common-path interferometer configuration for OCT, allowing easy exchange of probes for biomedical applications. The simultaneous imaging+sensing capability is demonstrated on rat brains.
dc.description.statementofresponsibilityJiawen Li, Erik Schartner, Stefan Musolino, Bryden C. Quirk, Rodney W. Kirk, Heike Ebendorff-Heidepriem and Robert A. McLaughlin
dc.identifier.citationOptics Letters, 2018; 43(8):1682-1685
dc.identifier.doi10.1364/OL.43.001682
dc.identifier.issn0146-9592
dc.identifier.issn1539-4794
dc.identifier.orcidLi, J. [0000-0001-8818-6070]
dc.identifier.orcidSchartner, E. [0000-0003-1669-4302]
dc.identifier.orcidMusolino, S. [0000-0003-2429-574X]
dc.identifier.orcidEbendorff-Heidepriem, H. [0000-0002-4877-7770]
dc.identifier.orcidMcLaughlin, R. [0000-0001-6947-5061]
dc.identifier.urihttp://hdl.handle.net/2440/112112
dc.language.isoen
dc.publisherOptical Society of America
dc.relation.granthttp://purl.org/au-research/grants/arc/CE140100003
dc.relation.granthttp://purl.org/au-research/grants/arc/DP150104660
dc.relation.granthttp://purl.org/au-research/grants/arc/LP110200736
dc.rights© 2018 Optical Society of America
dc.source.urihttps://doi.org/10.1364/OL.43.001682
dc.subjectBrain
dc.subjectAnimals
dc.subjectRats
dc.subjectDiagnostic Imaging
dc.subjectTomography, Optical Coherence
dc.subjectBody Temperature
dc.subjectEquipment Design
dc.subjectFiber Optic Technology
dc.subjectOptical Fibers
dc.titleMiniaturized single-fiber-based needle probe for combined imaging and sensing in deep tissue
dc.typeJournal article
pubs.publication-statusPublished

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