Epidemiology of community acquired sepsis in children in Australia and New Zealand: a multicentre prospective cohort study

Simple item page
dc.contributor.authorLong, E.
dc.contributor.authorBorland, M.L.
dc.contributor.authorGeorge, S.
dc.contributor.authorJani, S.
dc.contributor.authorTan, E.
dc.contributor.authorPhillips, N.
dc.contributor.authorKochar, A.
dc.contributor.authorCraig, S.
dc.contributor.authorLithgow, A.
dc.contributor.authorRao, A.
dc.contributor.authorWhyte, E.
dc.contributor.authorDalziel, S.
dc.contributor.authorHearps, S.
dc.contributor.authorGelbart, B.
dc.contributor.authorMcNab, S.
dc.contributor.authorBalamuth, F.
dc.contributor.authorWeiss, S.L.
dc.contributor.authorKuppermann, N.
dc.contributor.authorWilliams, A.
dc.contributor.authorBabl, F.E.
dc.date.issued2025
dc.description.abstractBackground: Paediatric sepsis epidemiology is unclear due to variability in case ascertainment. We describe the epidemiology of community acquired sepsis in Australian and New Zealand children using the Phoenix sepsis criteria. Methods: Prospective observational study conducted in 11 hospitals through the Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network from April 2021 to December 2023. Children aged 0–<18 years with suspected sepsis were included. Demographic information, therapies administered, and outcomes were collected, and the Phoenix sepsis criteria were applied. Findings: Of 822,072 children assessed, 6232 (0.8%) children had suspected sepsis and 306 (<0.1%) met the Phoenix sepsis criteria. Children who met the Phoenix sepsis criteria had higher rates of intensive care unit admission (245/ 306; 80.1% vs 1080/6232; 17.3%), vasoactive infusion (144/306; 47.1% vs 179/6232; 2.9%) mechanical ventilation (146/306; 47.7% vs 251/6232; 4.0%), and extracorporeal life support (12/306; 3.9% vs 13/6232; 0.2%) compared to the overall cohort. Intensive care unit and hospital length of stay were longer for those meeting Phoenix sepsis criteria than for the overall cohort (median 48.4 h vs 79.8 h and 69.7 h vs 189.8 h, respectively). Overall, 87/6232 (1.4%) patients died within 90 days, 42/306 (13.7%) of whom met Phoenix sepsis criteria. Interpretation: Hospitalisation for suspected sepsis was relatively infrequent. The Phoenix sepsis criteria identified children with more severe illness and worse outcomes, but underestimated the overall burden of sepsis.
dc.description.statementofresponsibilityElliot Long, Meredith L. Borland, Shane George, Shefali Jani, Eunicia Tan, Natalie Phillips, Amit Kochar, Simon Craig, Anna Lithgow, Arjun Rao, Emma Whyte, Stuart Dalziel, Stephen Hearps, Ben Gelbart, Sarah McNab, Fran Balamuth, Scott L. Weiss, Nathan Kuppermann, Amanda Williams, and Franz E. Babl, on behalf of the Paediatric Research in Emergency Departments International Collaborative (PREDICT) network
dc.identifier.citationThe Lancet Regional Health. Western Pacific, 2025; 60:101608-1-101608-8
dc.identifier.doi10.1016/j.lanwpc.2025.101608
dc.identifier.issn2666-6065
dc.identifier.issn2666-6065
dc.identifier.urihttps://hdl.handle.net/2440/147825
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT2017605
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT2034194
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT2017605
dc.rights© 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.source.urihttps://doi.org/10.1016/j.lanwpc.2025.101608
dc.subjectSepsis; Child; Organ dysfunction; Epidemiology
dc.titleEpidemiology of community acquired sepsis in children in Australia and New Zealand: a multicentre prospective cohort study
dc.typeJournal article
pubs.publication-statusPublished

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
hdl_147825.pdf
Size:
347.71 KB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Research Outputs