Should endometrial polyps be removed in patients with postmenopausal bleeding? - an assessment of study designs and report of a failed randomised controlled trial (ISRCTN73825127)
Date
2009
Authors
Timmermans, A.
Veersema, S.
van Kerkvoorde, T.
van der Voet, L.
Opmeer, B.
Bongers, M.
Mol, B.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
BJOG: an International Journal of Obstetrics and Gynaecology, 2009; 116(10):1391-1395
Statement of Responsibility
A Timmermans, S Veersema, TC van Kerkvoorde, LF van der Voet, BC Opmeer, MY Bongers, BWJ Mol
Conference Name
Abstract
We describe the design of a randomised controlled trial to evaluate the efficacy of endometrial polyp removal in women with postmenopausal bleeding. We designed a trial in which patients with postmenopausal bleeding and endometrial thickness >4 mm undergo hysteroscopy. If during hysteroscopy an endometrial polyp was diagnosed, patients were asked to participate in this trial and after informed consent allocated to immediate removal of the polyp or expectant management. This trial suffered from lack of recruitment related both to doctors seeking for informed consent as well as to patients’ unwillingness to participate in this trial. However, a randomised controlled trial on this subject is still necessary to evaluate the efficacy of uterine cavity evaluation in the diagnostic work-up of women with postmenopausal bleeding, focussing on benign pathology. Therefore, we propose an alternative design, which might be more feasible.
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Dissertation Note
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Description
Article first published online: 10 AUG 2009
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© 2009 The Authors