Successful control of Scedosporium prolificans septic arthritis and probable osteomyelitis without radical surgery in a long-term renal transplant recipient
Date
2008
Authors
Li, J.
Yong, T.
Grove, D.
Coates, P.
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Advisors
Journal Title
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Journal article
Citation
Transplant Infectious Disease, 2008; 10(1):63-65
Statement of Responsibility
J.Y.Z. Li, T.Y. Yong, D.I. Grove and P.T.H. Coates
Conference Name
Abstract
Scedosporium species are increasingly isolated from immunocompromised and immunocompetent patients. Scedosporium infections are generally resistant to multiple antifungals, and Scedosporium prolificans is particularly resistant to all single antifungal agents currently in use with in vitro testing. We report here a long-term renal transplant recipient who developed isolated S. prolificans septic monoarthritis and probable osteomyelitis. The infection was successfully treated with a combination of voriconazole and terbinafine in addition to joint washout but did not require radical surgery. This combination has been shown to have synergistic in vitro effect, and anecdotal in vivo success has also been reported recently. We also review the clinical presentation, treatment, and outcome of S. prolificans infection in patients with solid organ transplantation.
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Dissertation Note
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© 2008 John Wiley & Sons A/S