New drugs for HDL-C disorders: the beginning

Date

2014

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Duong, M.
Nicholls, S.

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Current Medicinal Chemistry, 2014; 21(25):2947-2951

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MyNgan Duong and Stephen J. Nicholls

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Abstract

For more than 20 years there has been increasing interest in the development of novel therapies to raise levels of high-density lipoprotein cholesterol (HDL-C). However, well publicized failures of recent clinical trials of agents that raise HDL-C levels have stimulated considerable controversy with regard to the potential clinical utility of this therapeutic target. A number of classes of agents are currently under investigation with variable effects on HDL quantity and quality. These will be reviewed.

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© 2016 Bentham Science Publishers

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