A critical role of interleukin-1 in preterm labor
| dc.contributor.author | Nadeau-Vallée, M. | |
| dc.contributor.author | Obari, D. | |
| dc.contributor.author | Quiniou, C. | |
| dc.contributor.author | Lubell, W.D. | |
| dc.contributor.author | Olson, D.M. | |
| dc.contributor.author | Girard, S. | |
| dc.contributor.author | Chemtob, S. | |
| dc.date.issued | 2016 | |
| dc.description.abstract | Preterm birth (PTB) is a leading cause of neonatal mortality and morbidity worldwide, and represents a heavy economic and social burden. Despite its broad etiology, PTB has been firmly linked to inflammatory processes. Pro-inflammatory cytokines are produced in gestational tissues in response to stressors and can prematurely induce uterine activation, which precedes the onset of preterm labor. Of all cytokines implicated, interleukin (IL)-1 has been largely studied, revealing a central role in preterm labor. However, currently approved IL-1-targeting therapies have failed to show expected efficacy in pre-clinical studies of preterm labor. Herein, we (a) summarize animal and human studies in which IL-1 or IL-1-targeting therapeutics are implicated with preterm labor, (b) focus on novel IL-1-targeting therapies and diagnostic tests, and (c) develop the case for commercialization and translation means to hasten their development. | |
| dc.description.statementofresponsibility | Mathieu Nadeau-Vallée, Dima Obari, Christiane Quiniou, William D.Lubell, David M.Olson, Sylvie Girard, Sylvain Chemtob | |
| dc.identifier.citation | Cytokine and Growth Factor Reviews, 2016; 28:37-51 | |
| dc.identifier.doi | 10.1016/j.cytogfr.2015.11.001 | |
| dc.identifier.issn | 1359-6101 | |
| dc.identifier.issn | 1879-0305 | |
| dc.identifier.uri | http://hdl.handle.net/2440/119887 | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.rights | © 2015 Elsevier Ltd. All rights reserved. | |
| dc.source.uri | https://doi.org/10.1016/j.cytogfr.2015.11.001 | |
| dc.subject | Preterm birth; Preterm labor; interleukin-1; inflammation; infection | |
| dc.title | A critical role of interleukin-1 in preterm labor | |
| dc.type | Journal article | |
| pubs.publication-status | Published |