Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses

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dc.contributor.authorCroker, B.
dc.contributor.authorHandman, E.
dc.contributor.authorHayball, J.
dc.contributor.authorBaldwin, T.
dc.contributor.authorVoigt, V.
dc.contributor.authorCluse, L.
dc.contributor.authorYang, F.
dc.contributor.authorWilliams, D.
dc.contributor.authorRoberts, A.
dc.date.issued2002
dc.description.abstractThe haematopoietic-specific RhoGTPase, Rac2, has been indirectly implicated in T-lymphocyte development and function, and as a pivotal regulator of T Helper 1 (TH1) responses. In other haematopoietic cells it regulates cytoskeletal rearrangement downstream of extracellular signals. Here we demonstrate that Rac2 deficiency results in an abnormal distribution of T lymphocytes in vivo and defects in T-lymphocyte migration and filamentous actin generation in response to chemoattractants in vitro. To investigate the requirement for Rac2 in IFN-gamma production and TH1 responses in vivo, Rac2-deficient mice were challenged with Leishmania major and immunized with ovalbumin-expressing cytomegalovirus. Despite a minor skewing towards a TH2 phenotype, Rac2-deficient mice displayed no increased susceptibility to L. major infection. Cytotoxic T-lymphocyte responses to cytomegalovirus and ovalbumin were also normal. Although Rac2 is required for normal T-lymphocyte migration, its role in the generation of TH1 responses to infection in vivo is largely redundant.
dc.description.statementofresponsibilityBen A Croker, Emanuela Handman, John D Hayball, Tracey M Baldwin, Valentina Voigt, Leonie A Cluse, Feng-Chun Yang, David A Williams and Andrew W Roberts
dc.identifier.citationImmunology and Cell Biology, 2002; 80(3):231-240
dc.identifier.doi10.1046/j.1440-1711.2002.01077.x
dc.identifier.issn0818-9641
dc.identifier.issn1440-1711
dc.identifier.orcidHayball, J. [0000-0002-3089-4506]
dc.identifier.urihttp://hdl.handle.net/2440/9505
dc.language.isoen
dc.publisherBlackwell Publishing Asia
dc.rights© 2002 Australasian Society for Immunology
dc.source.urihttps://doi.org/10.1046/j.1440-1711.2002.01077.x
dc.subjectchemotaxis
dc.subjectRac2
dc.subjectT lymphocytes
dc.subjectTH1/TH2
dc.titleRac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in TH1 responses
dc.typeJournal article
pubs.publication-statusPublished

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