Prenatal exposure to SKF-38393 alters the response to light of adult rats
Date
2000
Authors
Ferguson, S.
Kennaway, D.
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Journal article
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NeuroReport, 2000; 11(7):1539-1541
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Sally A. Ferguson and David J. Kennaway
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Abstract
The current study examined the consequences of prenatal SKF-38393 exposure on the cellular response in the adult suprachiasmatic nuclei to light. Pregnant rats were injected with the dopamine agonist SKF-38393 or vehicle daily from gestational day 15 to 21. Adult offspring received a light pulse (1 min/2 lux) 4 or 8 h after lights off (ZT16 or ZT20 where ZT = zeitgeber time). Brains were processed for c-FOS-like immunoreactivity in the SCN. At ZT20 the number of cells expressing c-FOS protein after a light pulse was the same in both groups. At ZT16 the number of cells in the SCN of SKF-38393-exposed animals was 58% lower than the vehicle-treated group. The data suggest that prenatal SKF-38393 treatment may have long-term consequences for SCN function.
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© 2000 Lippincott Williams & Wilkins