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Rapid detection of influenza A virus in clinical samples using an ion channel switch biosensor

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dc.contributor.authorOh, S.
dc.contributor.authorCornell, B.
dc.contributor.authorSmith, D.
dc.contributor.authorHiggins, G.
dc.contributor.authorBurrell, C.
dc.contributor.authorKok, T.
dc.date.issued2008
dc.descriptionCopyright © 2007 Elsevier B.V. All rights reserved.
dc.description.abstractThis report describes the fabrication and successful use of the ion channel switch biosensor (ICSB) for rapid point-of-care detection of influenza A in different types of respiratory specimens. Virus culture -- regarded as the "gold standard" -- and an immunochromatographic rapid point-of-care test for influenza A virus were compared with the biosensor. The ICSB rapid test provided an objective readout within 10 min of specimen inoculation into the ICSB chamber wells, without the need for chemical or other pretreatments. Construction of the ICSB with specific antibodies also enables rapid detection and identification of appropriate influenza A subtypes.
dc.description.statementofresponsibilityS.Y. Oh, B. Cornellc, D. Smith, G. Higgins, C.J. Burrell and T.W. Kok
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/405913/description#description
dc.identifier.citationBiosensors and Bioelectronics, 2008; 23(7):1161-1165
dc.identifier.doi10.1016/j.bios.2007.10.011
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.orcidBurrell, C. [0000-0002-4020-349X]
dc.identifier.urihttp://hdl.handle.net/2440/52264
dc.language.isoen
dc.publisherElsevier Advanced Technology
dc.source.urihttps://doi.org/10.1016/j.bios.2007.10.011
dc.subjectHumans
dc.subjectInfluenza A virus
dc.subjectIons
dc.subjectImmunoassay
dc.subjectViral Load
dc.subjectSensitivity and Specificity
dc.subjectReproducibility of Results
dc.subjectEquipment Design
dc.subjectEquipment Failure Analysis
dc.subjectBiosensing Techniques
dc.subjectComputer Systems
dc.titleRapid detection of influenza A virus in clinical samples using an ion channel switch biosensor
dc.typeJournal article
pubs.publication-statusPublished

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