Hybrid fluorescent curcumin loaded zein electrospun nanofibrous scaffold for biomedical applications
Date
2012
Authors
Brahatheeswaran, D.
Mathew, A.
Aswathy, R.G.
Nagaoka, Y.
Venugopal, K.
Yoshida, Y.
Maekawa, T.
Sakthikumar, D.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Biomedical Materials (Bristol), 2012; 7(4, article no. 045001):1-16
Statement of Responsibility
Conference Name
Abstract
Nanomedicine utilizes engineered nanodevices and nanostructures for monitoring, repair, construction and control of human biological systems at the molecular level. In this study, we investigated the feasibility and potential of zein nanofiber as a delivery vehicle for curcumin in biomedical applications. By optimizing the electrospinning parameters, ultrafine zein fluorescence nanofibers containing curcumin were developed with interconnected fibrous networks. We found that these nanofibers show an increase in fluorescence due to the incorporation of curcumin. The morphology and material properties of the resulting multifunctional nanofiber including the surface area were examined by a field emission-scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and confocal microscopy. The surface area and pore size were characterized by N2 adsorption-desorption isotherm. SEM and fluorescence images showed that the uniform fibers with smooth surface had an average diameter of about 310 nm. An in vitro degradation study showed significant morphological changes. The in vitro evaluations suggested that the curcumin incorporated zein nanofibers showed sustained release of curcumin and maintained its free radical scavenging ability. It provides an attractive structure for the attachment and growth of fibroblast as cell culture surfaces. The results demonstrate that the curcumin loaded zein nanofiber could be a good candidate for soft tissue engineering scaffolds and has the potential for further applications in drug delivery system.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright 2012 IOP Publishing