Altered fractionation in radiotherapy: From radiobiological rationale to therapeutic gain

Date

2010

Authors

Marcu, L.

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Journal article

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Cancer Treatment Reviews, 2010; 36(8):606-614

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Loredana G. Marcu

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Abstract

The implementation of altered fractionation schedules in clinical practice came as a need to improve loco-regional control and survival in those cancer patient groups which did not respond satisfactorily to conventionally fractionated radiotherapy. The current review aims to present the radiobiological rationale behind various non-conventional treatment schedules including the encountered challenges, through a compilation of clinical studies/trials and their contribution towards therapeutic gain.

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© 2010 Elsevier Ltd. All rights reserved.

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