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Intensity dependent repetitive transcranial magnetic stimulation modulation of blood oxygenation

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dc.contributor.authorThomson, R.H.
dc.contributor.authorRogasch, N.C.
dc.contributor.authorMaller, J.J.
dc.contributor.authorDaskalakis, Z.J.
dc.contributor.authorFitzgerald, P.B.
dc.date.issued2012
dc.description.abstractBackground: Repetitive transcranial magnetic stimulation (rTMS) is increasingly being investigated in clinical settings for the treatment of neurological and psychiatric disorders such as dystonia, schizophrenia, and major depressive disorder (MDD). Using near infra-red spectroscopy (NIRS), very short trains of rTMS have previously been shown to modulate cortical blood oxygenation. Methods: In order to investigate the effect of longer, clinically relevant trains of 1 Hz rTMS on oxy-hemoglobin (HbO) at prefrontal cortex, the current study applied ten minute trains of rTMS at both subthreshold and suprathreshold intensities. Results: A similar profile of oxygenation change was observed during the beginning 30-40 s of the trains, however for the remainder, subthreshold rTMS returned to baseline while the suprathreshold TMS resulted in a long period of reduced oxygenation. Limitations: Small sample size. Conclusions: The differences observed may be a product of changes in HbO requirements by inhibitory/excitatory neural circuits, either by reduced HbO demand or by increased HbO consumption, while sustained HbO reduction may be a consequence of a modulation of vaso-motor reactivity. This study has implications for understanding the mechanisms involved in the physiological changes evoked by rTMS and efficacious clinical application of rTMS in disorders such as MDD.
dc.description.statementofresponsibilityRichard H. Thomson, Nigel C. Rogasch, Jerome J. Maller, Zafiris J. Daskalakis, Paul B. Fitzgerald
dc.identifier.citationJournal of Affective Disorders, 2012; 136(3):1243-1246
dc.identifier.doi10.1016/j.jad.2011.08.005
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.orcidRogasch, N.C. [0000-0002-4484-1069]
dc.identifier.urihttp://hdl.handle.net/2440/120572
dc.language.isoen
dc.publisherElsevier
dc.relation.grantARC
dc.relation.grantNHMRC
dc.rights© 2011 Elsevier B.V. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.jad.2011.08.005
dc.subjectTranscranial magnetic stimulation; blood oxygenation; prefrontal cortex; major depressive disorder
dc.titleIntensity dependent repetitive transcranial magnetic stimulation modulation of blood oxygenation
dc.typeJournal article
pubs.publication-statusPublished

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