Early red cell transfusion favourably alters cerebral oxygen extraction in very preterm newborns
Date
2015
Authors
Andersen, C.
Karayil, S.
Hodyl, N.
Stark, M.
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Journal article
Citation
Archives of Disease in Childhood: Fetal and Neonatal Edition, 2015; 100(5):F433-F435
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CC Andersen, SM Karayil, NA Hodyl, MJ Stark
Conference Name
Abstract
Elevated cerebral fractional tissue oxygen extraction (cFTOE; ≥0.4) predicts early brain injury in very preterm infants. While blood transfusion increases oxygen-carrying capacity, its ability to improve cerebral oxygen kinetics in the immediate newborn period remains unknown.To investigate the effect of red blood cell (RBC) transfusion in the first 24 h of life on cFTOE in infants ≤29 weeks gestation.cFTOE was calculated from cerebral tissue oxygenation index (TOI) and cutaneous oximetry measured over a 30 min epoch before and after transfusion. Infants were dichotomised according to pre-transfusion cFTOE (low <0.4 vs high ≥0.4).24 babies were included, 12 in each group. Pre- and post-transfusion Hb were similar between the groups. cFTOE significantly reduced after transfusion in the high but not low-extraction group (p<0.01).Early RBC transfusion favourably alters cerebral oxygen kinetics in infants with elevated cFTOE, showing potential for modification of the risk of hypoxic (brain) injury.
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Short research report