1,2,3-Triazolyl amino acids as AMPA receptor ligands
Date
2010
Authors
Stanley, N.
Pedersen, D.
Nielsen, B.
Kvist, T.
Mathiesen, J.
Brauner-Osborne, H.
Taylor, D.
Abell, A.
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Advisors
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Journal article
Citation
Bioorganic and Medicinal Chemistry Letters, 2010; 20(24):7512-7515
Statement of Responsibility
N. J. Stanley, D. Sejer Pedersen, B. Nielsen, T. Kvist, J. M. Mathiesen, H. Bräuner-Osborne, D. K. Taylor and A. D. Abell
Conference Name
Abstract
The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
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Copyright 2010 Elsevier Ltd. All rights reserved.