Identification of a second presenilin gene in zebrafish with similarity to the human Alzheimer's disease gene presenilin2
Date
2002
Authors
Groth, C.
Nornes, S.
Mc Carty, R.
Tamme, R.
Lardelli, M.
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Journal article
Citation
Development Genes and Evolution, 2002; 212(10):486-490
Statement of Responsibility
Casper Groth, Svanhild Nornes, Rosa McCarty, Richard Tamme and Michael Lardelli
Conference Name
Abstract
Presenilins play prominent roles in the molecular pathogenesis of Alzheimer’s disease and during embryo development. We have isolated a zebrafish presenilin orthologue (pre2), which shows a high degree of sequence identity to the human PS2 protein. Zebrafish pre2 is maternally and ubiquitously expressed during early embryo development, whereas Pre2 protein expression is initiated between 6 and 12 hours post fertilisation (hpf), suggesting strict regulation of pre2 translation. pre2 expression is especially high in neural-crest-derived melanocytes.
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© Springer-Verlag 2002 The original publication can be found at www.springerlink.com