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The five year reproducibility of calcium-related biochemical variables in postmenopausal women

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dc.contributor.authorMorris, H.
dc.contributor.authorCleghorn, D.
dc.contributor.authorNeed, A.
dc.contributor.authorHorowitz, M.
dc.contributor.authorNordin, B.
dc.date.issued1995
dc.description.abstractA total of 19 measured and derived bone-related biochemical variables were determined in 307 postmenopausal volunteers on two occasions, 5 years apart. The plasma variables with the highest coefficients of determination (r2) were plasma globulins, alkaline phosphatase, creatinine and calculated ionized and ultrafiltrable calcium. In the urine, the highest r2 values were in respect of fasting urine calcium excretion corrected for urine sodium, hydroxyproline excretion, and the maximal renal tubular reabsorption of calcium and phosphate (TmCa/GFR and TmP/GFR). The components of variance of TmCa/GFR and TmP/GFR show marked individuality but their methods determination meet the criterion for acceptable analytical goals. We conclude that most of the measured and derived bone-related biochemical variables in fasting plasma and urine are sufficiently reproducible in postmenopausal women to be useful for ranking individuals for a period up to 5 years.
dc.description.statementofresponsibilityH. A. Morris, D. B. Cleghorn, A. G. Need, M. Horowitz and B. E. C. Nordin
dc.identifier.citationScandinavian Journal of Clinical and Laboratory Investigation, 1995; 55(5):383-389
dc.identifier.doi10.3109/00365519509104977
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.urihttp://hdl.handle.net/2440/9153
dc.language.isoen
dc.publisherInforma Healthcare
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.3109/00365519509104977
dc.subjectBiochemistry, bone markers, menopause, reproducibility
dc.titleThe five year reproducibility of calcium-related biochemical variables in postmenopausal women
dc.typeJournal article
pubs.publication-statusPublished

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