Ecdysone controlled cell and tissue deletion
Date
2020
Authors
Xu, T.
Jiang, X.
Denton, D.
Kumar, S.
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Journal article
Citation
Cell Death and Differentiation, 2020; 27(1):1-14
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Tianqi Xu, Xin Jiang, Donna Denton, Sharad Kumar
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Abstract
The removal of superfluous and unwanted cells is a critical part of animal development. In insects the steroid hormone ecdysone, the focus of this review, is an essential regulator of developmental transitions, including molting and metamorphosis. Like other steroid hormones, ecdysone works via nuclear hormone receptors to direct spatial and temporal regulation of gene transcription including genes required for cell death. During insect metamorphosis, pulses of ecdysone orchestrate the deletion of obsolete larval tissues, including the larval salivary glands and the midgut. In this review we discuss the molecular machinery and mechanisms of ecdysone-dependent cell and tissue removal, with a focus on studies in Drosophila and Lepidopteran insects.
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Link to a related website: https://www.nature.com/articles/s41418-019-0456-9.pdf, Open Access via Unpaywall
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© The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2019.