Long-term Survival and Life Expectancy Following an Acute Heart Failure Hospitalisation in Australia and New Zealand.

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dc.contributor.authorHariharaputhiran, S.
dc.contributor.authorPeng, Y.
dc.contributor.authorNgo, L.
dc.contributor.authorAli, A.
dc.contributor.authorHossain, S.
dc.contributor.authorVisvanathan, R.
dc.contributor.authorAdams, R.
dc.contributor.authorChan, W.
dc.contributor.authorRanasinghe, I.
dc.date.issued2022
dc.description.abstractAims: Contemporary long-term survival following a heart failure (HF) hospitalization is uncertain. We evaluated survival up to 10 years after a HF hospitalization using national data from Australia and New Zealand, identified predictors of survival, and estimated the attributable loss in life expectancy. Methods and results: Patients hospitalized with a primary diagnosis of HF from 2008–2017 were identified and all-cause mortality assessed by linking with Death Registries. Flexible parametric survival models were used to estimate survival, predictors of survival and loss in life expectancy. A total of 283 048 patients with HF were included (mean age 78.2±12.3 years, 50.8% male). Of these, 48.3% (48.1–48.5) were surviving by 3 years, 34.1% (33.9–34.3) by 5 years and 17.1% (16.8–17.4) by 10 years (median survival 2.8 years). Survival declined with age with 53.4% of patients aged 18–54 years and 6.2% aged ≥85 years alive by 10 years (adjusted hazard ratio [aHR] for mortality 4.84, 95% confidence interval [CI] 4.65–5.04 for ≥85 years vs. 18–54 years) and was worse in male patients (aHR 1.14, 95% CI 1.13–1.15). Prior HF (aHR 1.20, 95% CI 1.18–1.22), valvular and rheumatic heart disease (aHR 1.11, 95% CI 1.10–1.13) and vascular disease (aHR 1.07, 95% CI 1.04–1.09) were cardiovascular comorbidities most strongly associated with long-term death. Non-cardiovascular comorbidities and geriatric syndromes were common and associated with higher mortality. Compared with the general population, HF was associated with a loss of 7.3 years in life expectancy (or 56.6% of the expected life expectancy) and reached 20.5 years for those aged 18–54 years. Conclusion: Less than one in five patients hospitalized for HF were surviving by 10 years with patients experiencing almost 60% loss in life expectancy compared with the general population, highlighting the considerable persisting societal burden of HF. Concerted multidisciplinary efforts are needed to improve post-hospitalization outcomes of HF.
dc.description.statementofresponsibilitySaranya Hariharaputhiran, Yang Peng, Linh Ngo, Anna Ali, Sadia Hossain, Renuka Visvanathan, Robert Adams, Wandy Chan, and Isuru Ranasinghe
dc.identifier.citationEuropean Journal of Heart Failure, 2022; 24(9):1519-1528
dc.identifier.doi10.1002/ejhf.2595
dc.identifier.issn1388-9842
dc.identifier.issn1879-0844
dc.identifier.orcidAli, A. [0000-0002-7832-1694]
dc.identifier.orcidVisvanathan, R. [0000-0002-1303-9479]
dc.identifier.orcidAdams, R. [0000-0002-7572-0796]
dc.identifier.urihttps://hdl.handle.net/2440/146121
dc.language.isoen
dc.publisherWiley
dc.rights© 2022 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.source.urihttps://doi.org/10.1002/ejhf.2595
dc.subjectHeart failure; Hospitalizations; Survival; Prognosis; Mortality; Outcomes
dc.subject.meshHumans
dc.subject.meshHospitalization
dc.subject.meshLife Expectancy
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAustralia
dc.subject.meshNew Zealand
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshHeart Failure
dc.titleLong-term Survival and Life Expectancy Following an Acute Heart Failure Hospitalisation in Australia and New Zealand.
dc.typeJournal article
pubs.publication-statusPublished online

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