Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.
Date
2022
Authors
Fitzgerald, S.
Akhtar, J.
Schartner, E.
Ebendorff-Heidepriem, H.
Mahadevan-Jansen, A.
Li, J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Biophotonics, 2022; 16(3):1-22
Statement of Responsibility
Sean Fitzgerald, Jobaida Akhtar, Erik Schartner, Heike Ebendorff-Heidepriem, Anita Mahadevan-Jansen, Jiawen Li
Conference Name
Abstract
Optical techniques hold great potential to detect and monitor disease states as they are a fast, non-invasive toolkit. Raman spectroscopy (RS) in particular is a powerful label-free method capable of quantifying the biomolecular content of tissues. Still, spontaneous Raman scattering lacks information about tissue morphology due to its inability to rapidly assess a large field of view. Optical Coherence Tomography (OCT) is an interferometric optical method capable of fast, depth-resolved imaging of tissue morphology, but lacks detailed molecular contrast. In many cases, pairing label-free techniques into multimodal systems allows for a more diverse field of applications. Integrating RS and OCT into a single instrument allows for both structural imaging and biochemical interrogation of tissues and therefore offers a more comprehensive means for clinical diagnosis. This review summarizes the efforts made to date toward combining spontaneous RS-OCT instrumentation for biomedical analysis, including insights into primary design considerations and data interpretation.
School/Discipline
Dissertation Note
Provenance
Description
Published March 2023
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Rights
© 2022 Wiley-VCH GmbH.