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Effects of variations in intragastric volume on blood pressure and splanchnic blood flow during intraduodenal glucose infusion in healthy older subjects

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dc.contributor.authorVanis, L.
dc.contributor.authorGentilcore, D.
dc.contributor.authorLange, K.
dc.contributor.authorGilja, O.
dc.contributor.authorRigda, R.
dc.contributor.authorTrahair, L.
dc.contributor.authorFeinle-Bisset, C.
dc.contributor.authorRayner, C.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.
dc.date.issued2012
dc.description.abstractThe postprandial reduction in blood pressure (BP) is triggered by the interaction of nutrients with the small intestine and associated with an increase in splanchnic blood flow. Gastric distension may attenuate the postprandial fall in BP. The aim of this study was to determine the effects of differences in intragastric volume, including distension at a low (100 ml) volume, on BP and superior mesenteric artery (SMA) blood flow responses to intraduodenal glucose in healthy older subjects. BP and heart rate (HR; automated device), SMA blood flow (Doppler ultrasound), mesenteric vascular resistance (MVR), and plasma norepinephrine of nine male subjects (65–75 yr old) were measured after an overnight fast on 4 separate days in random order. On each day, subjects were intubated with a nasoduodenal catheter, incorporating a duodenal infusion port, and orally with a second catheter, incorporating a barostat bag, positioned in the fundus. Each subject received a 60-min (t = 0–60 min) intraduodenal glucose infusion (3 kcal/min) and gastric distension at a volume of 1) 0 ml (V0), 2) 100 ml (V100), 3) 300 ml (V300), or 4) 500 ml (V500). Systolic BP fell (P < 0.05) during V0, but not during V100, V300, or V500. In contrast, HR (P < 0.01) and SMA blood flow (P < 0.001) increased and MVR decreased (P < 0.05) comparably on all 4 days. Plasma norepinephrine rose (P < 0.01) in response to intraduodenal glucose, with no difference between the four treatments. There was a relationship between the areas under the curve for the change in systolic BP from baseline with intragastric volume (r = 0.60, P < 0.001). In conclusion, low-volume (≤100 ml) gastric distension has the capacity to abolish the fall in BP induced by intraduodenal glucose in healthy older subjects without affecting SMA blood flow or MVR. These observations support the concept that nonnutrient gastric distension prior to a meal has potential therapeutic applications in the management of postprandial hypotension.
dc.description.statementofresponsibilityLora Vanis, Diana Gentilcore, Kylie Lange, Odd Helge Gilja, Rachael S. Rigda, Laurence G. Trahair, Christine Feinle-Bisset, Christopher K. Rayner, Michael Horowitz, and Karen L. Jones
dc.identifier.citationAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2012; 302(4):R391-R399
dc.identifier.doi10.1152/ajpregu.00464.2011
dc.identifier.issn0363-6119
dc.identifier.issn1522-1490
dc.identifier.orcidLange, K. [0000-0003-3814-8513]
dc.identifier.orcidRigda, R. [0000-0002-8924-5359]
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.urihttp://hdl.handle.net/2440/73028
dc.language.isoen
dc.publisherAmer Physiological Soc
dc.relation.grantNHMRC
dc.rightsCopyright © 2012 the American Physiological Society
dc.source.urihttps://doi.org/10.1152/ajpregu.00464.2011
dc.subjectbarostat
dc.subjectdistension
dc.subjectpostprandial hypotension
dc.titleEffects of variations in intragastric volume on blood pressure and splanchnic blood flow during intraduodenal glucose infusion in healthy older subjects
dc.typeJournal article
pubs.publication-statusPublished

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