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Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men

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dc.contributor.authorStewart, J.
dc.contributor.authorSeimon, R.
dc.contributor.authorOtto, B.
dc.contributor.authorKeast, R.
dc.contributor.authorClifton, P.
dc.contributor.authorFeinle-Bisset, C.
dc.date.issued2011
dc.description.abstractBackground: Both orosensory stimulation and feedback from the gastrointestinal tract contribute to energy intake regulation. Objective: We evaluated the hypothesis that overweight or obese subjects would be less sensitive to both oral and intraduodenal oleic acid exposure than would lean subjects. Design: Eleven overweight or obese and 8 lean men were studied on 2 occasions, during which antropyloroduodenal pressures, plasma cholecystokinin and peptide YY, and appetite were measured during 90-min intraduodenal infusions of saline or oleic acid (18:1 load: 0.78 kcal/min); energy intake (buffet lunch) was determined immediately afterward. Oral detection thresholds for 18:1 and recent dietary intake (2-d recall) were also quantified. Results: In lean subjects, the number of isolated pyloric pressure waves (IPPWs) was greater during 18:1 infusion than during saline infusion (P < 0.05); no significant differences were observed between the 18:1 and saline infusions in the overweight or obese subjects. In both groups, 18:1 stimulated plasma cholecystokinin and peptide YY and suppressed energy intake compared with saline (P < 0.05), with trends for reduced cholecystokinin and energy intake responses in the overweight or obese subjects. Detection thresholds for 18:1 were greater in overweight or obese (7.9 ± 0.1 mmol/L) than in lean (4.1 ± 0.4 mmol/L) subjects (P < 0.05). Overweight or obese subjects had greater recent energy (P < 0.05) and fat (P = 0.07) intakes than did lean subjects. There was a direct relation (r = 0.669) of body mass index with 18:1 detection thresholds and inverse relations (r < −0.51) of IPPWs with body mass index and 18:1 detection thresholds (P < 0.05). Conclusions: The ability to detect oleic acid both orally and within the gastrointestinal tract is compromised in obese men, and oral and gastrointestinal responses to oleic acid are related.
dc.description.statementofresponsibilityJessica E Stewart, Radhika V Seimon, Bärbel Otto, Russell SJ Keast, Peter M Clifton, and Christine Feinle-Bisset
dc.identifier.citationAmerican Journal of Clinical Nutrition, 2011; 93(4):703-711
dc.identifier.doi10.3945/ajcn.110.007583
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]
dc.identifier.urihttp://hdl.handle.net/2440/67180
dc.language.isoen
dc.publisherAmer Soc Clinical Nutrition
dc.rightsCopyright 2011 American Society for Nutrition
dc.source.urihttps://doi.org/10.3945/ajcn.110.007583
dc.subjectDuodenum
dc.subjectPylorus
dc.subjectHumans
dc.subjectObesity
dc.subjectThinness
dc.subjectCholecystokinin
dc.subjectPeptide YY
dc.subjectDietary Fats
dc.subjectOleic Acid
dc.subjectBody Mass Index
dc.subjectSensory Thresholds
dc.subjectTaste
dc.subjectEnergy Intake
dc.subjectAppetite Regulation
dc.subjectPressure
dc.subjectReference Values
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectYoung Adult
dc.titleMarked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men
dc.typeJournal article
pubs.publication-statusPublished

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