Caspase function in programmed cell death

Simple item page
dc.contributor.authorKumar, S.
dc.date.issued2007
dc.descriptionCopyright © 2007 Nature Publishing Group. All rights reserved.
dc.description.abstractThe first proapoptotic caspase, CED-3, was cloned from Caenorhabditis elegans in 1993 and shown to be essential for the developmental death of all somatic cells. Following the discovery of CED-3, caspases have been cloned from several vertebrate and invertebrate species. As reviewed in other articles in this issue of Cell Death and Differentiation, many caspases function in nonapoptotic pathways. However, as is clear from the worm studies, the evolutionarily conserved role of caspases is to execute programmed cell death. In this article, I will specifically focus on caspases that function primarily in cell death execution. In particular, the physiological function of caspases in apoptosis is discussed using examples from the worm, fly and mammals.
dc.description.statementofresponsibilityS Kumar
dc.identifier.citationCell Death and Differentiation, 2007; 14(1):32-43
dc.identifier.doi10.1038/sj.cdd.4402060
dc.identifier.issn1350-9047
dc.identifier.issn1476-5403
dc.identifier.orcidKumar, S. [0000-0001-7126-9814]
dc.identifier.urihttp://hdl.handle.net/2440/45413
dc.language.isoen
dc.publisherNature Publishing Group
dc.source.urihttp://www.nature.com/cdd/journal/v14/n1/pdf/4402060a.pdf
dc.subjectAnimals
dc.subjectHumans
dc.subjectCaspases
dc.subjectApoptosis
dc.subjectBiological Evolution
dc.titleCaspase function in programmed cell death
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Medicine publications