Functional tolerance to a-adrenergic receptor blockade in the spontaneously hypertensive rat highlights the multi-functional role of vascular angiotensin II in the development of hypertension

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dc.contributor.authorSmid, S.
dc.contributor.authorFrewin, D.
dc.contributor.authorWyartt, C.
dc.contributor.authorHead, R.
dc.date.issued1995
dc.description.abstractTreatment of spontaneously hypertensive rats (SHR) with α-adrenoceptor antagonists failed to alter the development of hypertension in this animal model. However, agents such as captopril (CAP) and losartan (LOS) which interfere with the renin-angiotensin system effectively prevented the development of hypertension. When tolerance occurred in the presence of doxazosin (DOX) or phenoxybenzamine, there was an enhanced sensitivity to the blood pressure lowering influence of LOS. In the presence of CAP, at a dose that did not retard the development of blood pressure in the SHR, DOX treatment significantly offset the development of hypertension in this strain. These results suggest that a functional tolerance to agents that interfere with the sympathetic nervous system is mediated by the renin-angiotensin system. Angiotensin-converting enzyme inhibition was associated with a normalization of the enhanced contraction of the mesenteric vascular bed seen in preparations from the SHR and a suppression in the development of the vascular amplifier. The results suggest that the sympathetic nervous system is unable to maintain an elevated blood pressure in the SHR during interference with the functioning of the renin-angiotensin system. Conversely, under conditions of α-adrenoceptor blockade, angiotensin II can maintain an elevated blood pressure in the SHR
dc.description.statementofresponsibilityS.D. Smid, D.B. Frewin, C.L. Wyartt and R.J. Head
dc.description.urihttp://www.karger.com.proxy.library.adelaide.edu.au/Article/Abstract/159099
dc.identifier.citationJournal of Vascular Research, 1995; 32(4):247-253
dc.identifier.doi10.1159/000159099
dc.identifier.issn1018-1172
dc.identifier.issn1423-0135
dc.identifier.orcidSmid, S. [0000-0003-4192-7219]
dc.identifier.orcidHead, R. [0000-0002-1196-0926]
dc.identifier.urihttp://hdl.handle.net/2440/14496
dc.language.isoen
dc.publisherS. Karger
dc.source.urihttps://doi.org/10.1159/000159099
dc.subjectAnimals
dc.subjectRats, Inbred SHR
dc.subjectRats, Inbred WKY
dc.subjectRats
dc.subjectHypertension
dc.subjectNorepinephrine
dc.subjectPhenoxybenzamine
dc.subjectBiphenyl Compounds
dc.subjectLosartan
dc.subjectTetrazoles
dc.subjectImidazoles
dc.subjectDoxazosin
dc.subjectCaptopril
dc.subjectAngiotensin II
dc.subjectAdrenergic alpha-Antagonists
dc.subjectBlood Pressure
dc.subjectDrug Tolerance
dc.titleFunctional tolerance to a-adrenergic receptor blockade in the spontaneously hypertensive rat highlights the multi-functional role of vascular angiotensin II in the development of hypertension
dc.typeJournal article
pubs.publication-statusPublished

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