Prevalence of coronary heart disease and cardiovascular risk factors in a national cross-sectional cohort study of systemic sclerosis

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dc.contributor.authorNgian, G.
dc.contributor.authorSahhar, J.
dc.contributor.authorProudman, S.
dc.contributor.authorStevens, W.
dc.contributor.authorWicks, I.
dc.contributor.authorVan Doornum, S.
dc.date.issued2012
dc.description.abstractOBJECTIVES To determine the prevalence of coronary heart disease (CHD) and cardiovascular risk factors in a well-characterised cohort of systemic sclerosis (SSc) patients, and to compare this with the general population. METHODS A cross-sectional study of the prevalence of CHD and cardiovascular risk factors in participants in the Australian Scleroderma Cohort Study was performed. Controls were drawn from the 2007–8 National Health Survey (NHS) and the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). OR and 95% CI were calculated to determine the prevalence of CHD and cardiovascular risk factors in SSc patients compared with controls. RESULTS Data were available for 850 SSc patients (86% female), 15 787 NHS participants (53% female) and 8802 AusDiab participants (56% female). Adjusted for age and gender, the OR of CHD in SSc patients was 1.9 (95% CI 1.4 to 2.4) compared with controls from AusDiab and 2.0 (95% CI 1.5 to 2.5) compared with controls from the NHS. The OR of CHD increased to 3.2 (95% CI 2.3 to 4.5) for SSc patients compared with controls from AusDiab after further adjustment for cardiovascular risk factors. Hypercholesterolaemia, diabetes mellitus and obesity were significantly less prevalent in the SSc cohort than in AusDiab. Within the SSc cohort, the presence of pulmonary arterial hypertension was associated with CHD. CONCLUSIONS This is the first report of an increased prevalence of CHD in SSc patients. Further studies are required to determine the relative contribution of scleroderma-specific factors such as microvascular disease to the development of CHD.
dc.description.statementofresponsibilityGene-Siew Ngian, Joanne Sahhar, Susanna M Proudman, Wendy Stevens, Ian P Wicks, Sharon Van Doornum
dc.identifier.citationAnnals of the Rheumatic Diseases, 2012; 71(12):1980-1983
dc.identifier.doi10.1136/annrheumdis-2011-201176
dc.identifier.issn1468-2060
dc.identifier.issn1468-2060
dc.identifier.orcidProudman, S. [0000-0002-3046-9884]
dc.identifier.urihttp://hdl.handle.net/2440/74862
dc.language.isoen
dc.publisherBMJ Group
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1023407
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1136/annrheumdis-2011-201176
dc.subjectHumans
dc.subjectCardiovascular Diseases
dc.subjectCoronary Disease
dc.subjectScleroderma, Systemic
dc.subjectHealth Surveys
dc.subjectPrevalence
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectCross-Sectional Studies
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectAustralia
dc.subjectFemale
dc.subjectMale
dc.titlePrevalence of coronary heart disease and cardiovascular risk factors in a national cross-sectional cohort study of systemic sclerosis
dc.typeJournal article
pubs.publication-statusPublished

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